探讨高龄冠心病患者脂类代谢与冠状动脉粥样硬化的相关性。
Toexplorethecorrelationbetweenlipidmetabolismandcoronaryatherosclerosisinadvancedagedpatientswithcoronaryheartdisease(CHD).选择年12月至年12月间因疑诊冠心病来我院行冠状动脉造影的95例高龄患者为研究对象，95例患者依据造影结果区分为冠心病组（43例），非冠心病组（52例）。对其临床资料进行回顾性分析，分析血脂与冠状动脉粥样硬化的相关性。
Atotalof95advancedagedpatients,whoweresuspectedCHDandreceivedcoronaryangiography(CAG)inourhospitalfromDectoDec,wereselected.AccordingtoCAGresults,the95patientsweredividedintoCHDgroup(n=43)andnon-CHDgroup(n=52).Theirclinicaldatawereretrospectivelyanalyzed,andthecorrelationsbetweenbloodlipidsandcoronaryatherosclerosiswereanalyzed.与非冠心病组比较，冠心病组低密度脂蛋白胆固醇/高密度脂蛋白胆固醇(LDL-C/HDL-C)比值[(2.01±0.65)比(2.38±0.92)，P=0.]显著升高。冠心病组冠状动脉病变支数与甘油三酯（TG）、LDL-C/HDL-C、TG/HDL-C、血浆致动脉硬化指数（AIP）均呈正相关（r=0.~0.,P均0.05），与HDL-C水平呈负相关（r=-0.，P0.05）。冠状动脉狭窄程度与LDL-C/HDL-C、TG/HDL-C、AIP呈正相关（r=0.~0.，P0.05）；与HDL-C水平呈负相关（r=-0.，P0.05）。冠心病组Gensini总积分与各项血脂指标及比值呈正相关（r=0.~0.，P0.05或0.01），与HDL-C水平呈负相关r=-0.，P0.01）。
Comparedwithnon-CHDgroup,theratiooflowdensitylipoproteincholesteroltohighdensitylipoproteincholesterol(LDL-C/HDL-C)[(2.01±0.65)vs.(2.38±0.92),P=0.]significantlyroseinCHDgroup.InCHDgroup,numberofdiseasedcoronaryvesselwaspositivelycorrelatedwithtriglyceride(TG)level,LDL-C/HDL-C,TG/HDL-Candatherogenicindexofplasma(AIP),r=0.~0.(P0.05all),andinverselycorrelatedwithHDL-Clevel(r=-0.,P0.05);coronarystenosisdegreewaspositivelycorrelatedwithLDL-C/HDL-C,TG/HDL-CandAIP(r=0.~0.,P0.05),andinverselycorrelatedwithHDL-Clevel(r=-0.,P0.05).InCHDgroup,totalGensiniscorewaspositivelycorrelatedwithbloodlipidindexes(r=0.~0.,P0.05or0.01)andinverselycorrelatedwithHDL-Clevel(r=-0.,P0.01).高龄冠心病患者血浆HDL-C水平升高能延缓冠心病进展，LDL-C/HDL-C比值、AIP是评估冠心病患者冠状动脉粥样硬化严重性及危险性的指标。
ElevatedplasmaHDL-Clevelcandelayprogressionofcoronaryheartdiseaseinadvancedagedpatientswithcoronaryheartdisease.LDL-C/HDL-CandAIPareindexesevaluatingseverityandriskofcoronaryatherosclerosisinpatientswithcoronaryheartdisease.更多内容，我们下期见~