患者男,45岁,既往有溃疡性结肠炎及直肠结肠切除术,术后三天出现发热及腹痛病史。此次因发现腹腔脓肿住院治疗。入院后给予静脉使用抗生素和脓肿引流治疗,经治疗后病情有所好转。但住院第7天体温38.5℃,同时皮肤出现疼痛性病变;皮损开始为脓疱,在48小时内逐渐形成斑块,并在背部和一侧颈部可见透明的水疱样外观。在患者的剖腹术中线疤痕上和耳朵上也发现了类似的病变。实验室结果提示白细胞计数为18×/L(参考范围,4-10×/L),中性粒细胞百分比为80%,血沉为40mm/h(参考范围,0-22mm/h)。其中一个病灶的活检显示中性粒细胞炎性浸润和上真皮水肿。诊断为Sweet综合征(也称为急性发热性嗜中性皮病)。开始口服泼尼松治疗。患者开始治疗后1天内体温下降,5天内皮损完全消退。
附原文:
A54-year-oldmanwhohadpreviouslyundergoneaproctocolectomyforulcerativecolitispresentedwitha3-dayhistoryoffeverandabdominalpain.Hewasfoundtohaveanintraabdominalabscessandwasadmittedtothehospital.Hisconditionwasimprovingwithtreatment,whichincludedintravenousantibioticagentsanddrainageoftheabscess.Onday7ofhishospitalstay,histemperaturewas38.5°C,andpainfulskinlesionsdeveloped;thelesionsstartedaspustulesandevolvedover48hourstoformplaqueswithatransparent,vesicle-likeappearanceonthebackandsideofhisneck.Similarlesionswerenotedonthepatient’smidlinelaparotomyscarandonhisears.Laboratorystudiesonday7showedawhite-cellcountof18×perliter(referencerange,4×to10×),80%neutrophils,andanerythrocytesedimentationrateof40mmperhour(referencerange,0to22).Biopsyofoneofthelesionsshowedinflammatoryinfiltratesofneutrophilsandedemaintheupperdermis.AdiagnosisoftheinflammatorydisorderSweet’ssyndrome(alsocalledacutefebrileneutrophilicdermatosis)wasmade.Treatmentwithoralprednisonewasinitiated.Thepatient’sfeverresolvedwithin1dayaftertreatmentbegan,andthelesionsresolved